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For general news from the Allen Institute for Cell Science, visit alleninstitute.org

Allen Cell Discussion Forum launched

9/27/2018

 
A new online discussion forum offers a meeting spot for the gene-editing and stem cell research community to interact with one another and with the scientists that created the Allen Institute's fluorescently tagged human induced pluripotent stem cell (hiPSC) line collection.
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Read & post on the forum

New article: "5 things we (still) don't know about cells" posted

9/24/2018

 
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Researchers at the Allen Institute for Cell Science were interviewed around the question "what don't we know about cells?" A full article summarizing their responses is available at alleninstitute.org.



Read the full article

Machine Learning Technique to Predict Human Cells' Organization Published in Nature Methods

9/17/2018

 
Scientists at the Allen Institute have used machine learning to train computers to see parts of the cell the human eye cannot easily distinguish. Using 3D images of fluorescently labeled cells, the research team taught computers to find structures inside living cells without fluorescent labels, using only black and white images generated by an inexpensive technique known as brightfield microscopy. A study describing the new technique is published today in the journal Nature Methods.
Read full press release

Jove Video Journal released

9/5/2018

 
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Our new Jove Video Journal article presents a protocol we developed for tagging endogenously expressed proteins with fluorescent tags in human induced pluripotent stem cells using CRISPR/Cas9. Putatively edited cells are enriched by fluorescence activated cell sorting and clonal cell lines are generated.

New fluorescently tagged cell lines available, including first ‘silent’ tagged line

6/19/2018

 
The Allen Cell Collection now contains five new fluorescently tagged stem cell lines, including the first cells in the collection with a tag specific to heart muscle cells, or cardiomyocytes. To date, all the cell lines have been gene edited to carry a fluorescent marker that is produced in undifferentiated cells, before they go on to become specific cell types, like cardiomyocytes, nerve cells or liver cells.
Read full article

Our 3rd ​Allen Cell Methods video released: Setting up the WTC parental line for cardiac differentiation

6/5/2018

 
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We have released a new Instructional Video.
To ensure researchers have success working with our human induced pluripotent stem cell lines in their lab, our Angel Nelson highlights nuanced techniques and helpful tips while demonstrating our cardiac differentiation protocol for the WTC parental line and our gene-edited cells. If the experiment is successful, you can expect to see beating cardiomyocytes at day 7.
View more videos

Allen Integrated Cell launches

5/9/2018

 
The Allen Institute for Cell Science today launched the Allen Integrated Cell, the world's first predictive and comprehensive 3D model of a live human cell. This new visualization of a large collection of human stem cells will allow researchers around the world to see structures inside a living cell together at the same time, providing a baseline for better understanding healthy cells and for studying human disease models.
Building off last year's launch of the Allen Cell Explorer, the Allen Integrated Cell comprises two different models that can predict the shape and location of cellular structures. The first, a probabilistic model, emerged from a machine learning approach that accurately predicts the most probable shape and location of structures in a cell based solely on the shape of that cell's plasma membrane and nucleus.
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New video provides an overview of our gene editing process

5/1/2018

 
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Follow our gene editing workflow from the initial transfection through the FACS enrichment and clonal line generation processes. This step-by-step video highlights the methods used by the Allen Institute for Cell Science researchers to generate hiPSC lines that are gene edited to express endogenous proteins fused to in-frame N- or C-terminal fluorescent tags using CRISPR/Cas9.

​Access more information detailing our scientific methods & standard operating procedures. Researchers can obtain these hiPS cells or plasmids through our Cell Catalog.

Our 2nd Allen Cell Methods video released: Ribonucleoprotein (RNP) transfection for gene editing hiPSCs

3/6/2018

 
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We have released a new Instructional Video.

To ensure researchers have success working with our cell lines, our Maggie Fuqua demonstrates our RNP transfection protocol for gene editing hiPSCs.
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Please come see us at Biophysical Society's Annual Meeting​ in San Francisco February 17-21!

2/14/2018

 
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In addition to hosting a VR cell tour at booth #311 in the exhibitor hall, researchers from the Allen Institute for Cell Science will present in several venues including:
  • a Platform Session on Computational Methods and Bioinformatics
  • in the Cell Biophysics Subgroup
  • an exhibitor session
  • and in front of 3 posters
​We look forward to seeing you at BPS!
Schedules & details for AICS at BPS 2018
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cellscience.alleninstitute.org
  • About
    • What We Do
    • FAQs
    • Videos & Tutorials
    • Site Updates
    • < Forum >
    • < AllenInstitute.org >
  • Animated Cell
    • Educational Resources
    • Visual Guide to Human Cells
    • Visual Guide Tutorial
    • Research Projects >
      • Pathtrace rendering
  • Cells & Biology
    • Cell Catalog
    • About our Cells >
      • hiPS Cell Biology Overview
      • Cell Structure Observations
      • Cell Catalog QuickView
    • Genomics
    • Methods & SOPs >
      • Methods for Cells in the Lab
      • Cell Methods: Videos from the Lab
      • Methods for Microscopy
    • Research Projects >
      • hiPS Cells During Mitosis
      • Drug Perturbation Pilot
      • Differentiation Into Cardiomyocytes
      • Why Endogenous Tagging?
  • Data & Tools
    • Cell Catalog
    • 3D Cell Viewer
    • Cell Feature Explorer
    • Integrated Mitotic Stem Cell Z-stack Viewer
    • Deep Cell Zoom
    • Segmenter
    • Data Downloading
    • Software & Code
    • Simularium
    • Research Projects >
      • Extracting Information
  • Modeling & Analysis
    • Integrated Mitotic Stem Cell
    • Allen Integrated Cell
    • Label-free Determination
    • Data Notebook Exploration >
      • Cell Shape Analysis
      • Programmatic Data Access
    • Research Projects >
      • 3D Probabilistic Modeling
  • News & Publications
    • News Feed
    • Publications
    • Archived Content